Case Report: Immunological Response to IVIG Treatment for Recurrent COVID-19

A 47-year-old female patient with neuromyelitis optica spectrum disorder developed prolonged COVID-19 pneumonia after rituximab treatment. The case report details longitudinal serologic analyses showing restoration of Fc-mediated effector functions following intravenous immunoglobulin (IVIG) therapy. The 664.0 KB document was authored by Hee Bum Jo and last updated on 2026-05-25.

Use Cases

• Analyze the relationship between B-cell depletion and persistent SARS-CoV-2 infection based on the patient's clinical course.
• Study the restoration of antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) functions based on longitudinal serologic data.
• Investigate the therapeutic mechanism of IVIG in COVID-19 based on IgG titer measurements against wild-type and Omicron variants.

Strengths

• Detailed longitudinal serologic analysis of a specific clinical case.
• Includes specific measurements of IgG titers and Fc-mediated effector functions.
• Document is licensed under CC-BY-4.0 for open sharing.

Limitations

• Data is a single case report, limiting statistical power and generalizability.
• Row count and column-level documentation are absent; data structure must be inferred from the text.
• The 664.0 KB size indicates a very limited scope, likely containing only the report document.

Provenance

Source

figshare, authored by Hee Bum Jo.

Collection Method

Clinical case report and associated serologic analysis.

Time Range

Covers the patient's clinical course and treatment period.

Freshness

Last updated 2026-05-25 06:03:40.