Synovial Sarcoma Case Report with Myxoid Stroma and Absent Epithelial Markers

A single clinical case report of a rare presentation of synovial sarcoma in a 61-year-old woman. The report details the diagnostic challenge, including imaging, histology, immunohistochemistry, and comprehensive genomic profiling that identified an SS18–SSX1 fusion gene. The data is a 661.0 KB document authored by Tomohiro Miyazaki and shared under a CC-BY-4.0 license on figshare.

Use Cases

• Training diagnostic classifiers to differentiate synovial sarcoma from other myxoid sarcomas based on the described histopathological and molecular features.
• Studying the correlation between specific fusion transcripts (SS18–SSX1) and unusual histological phenotypes like diffuse myxoid stroma.
• Benchmarking molecular diagnostic methods (FISH, RT-PCR, RNA sequencing) for confirming sarcoma diagnoses in challenging cases.
• Analyzing clinical outcomes, such as metastasis and recurrence, in synovial sarcoma cases with atypical presentation.

Strengths

• Includes detailed molecular confirmation via fluorescence in situ hybridization, reverse transcription polymerase chain reaction, and RNA sequencing.
• Provides a comprehensive longitudinal account covering initial presentation, diagnosis, treatment, and subsequent metastasis and recurrence.
• Document is shared under a permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• Row count is unknown, which may limit suitability assessment; the dataset is a single case report.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect the specific bias inherent to a single, rare case report from figshare.

Provenance

Source

figshare

Collection Method

Clinical case documentation and molecular analysis.

Freshness

Last updated 2026-05-29 04:52:17; freshness should be verified.