AMA-M6-like Antibody Patterns: Two Clinical Case Reports

A 2026 figshare upload by Elise Tolmer presents two clinical case reports of patients exhibiting an M6-like antimitochondrial antibody pattern not linked to the drug iproniazid. The report details patient histories, including one case associated with pembrolizumab immunotherapy and liver cytolysis, and another discovered fortuitously without liver damage. The document is a 69.3 KB PDF licensed under CC-BY-4.0.

Use Cases

• Training NLP models to extract clinical entities from case reports based on descriptions of patient treatment and symptoms.
• Analyzing the association between novel antibody patterns and specific immunotherapies like pembrolizumab mentioned in the description.
• Studying the clinical presentation and outcomes of rare autoimmune phenomena based on the detailed case narratives.
• Benchmarking information extraction systems on specialized medical text describing immunofluorescence patterns and liver enzyme levels.

Strengths

• The dataset is a detailed clinical case report with specific patient timelines, such as a 20-day onset post-immunotherapy.
• It provides a clear comparison to existing literature, challenging the established link between AMA-M6 and iproniazid.
• The data is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is a single PDF document of 69.3 KB, representing an extremely limited scope of two cases.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical tasks.

Provenance

Source

Elise Tolmer via figshare.

Collection Method

Clinical case report.

Freshness

Last updated 2026-05-29 06:07:39.