Table 1_Causal risk and protective factors for rheumatoid arthritis: a comprehensive mende

Xu Han's dataset compiles evidence from 117 Mendelian randomization studies, covering 496 associations across 248 unique exposures for rheumatoid arthritis. The data includes meta-analysis results for 200 exposure-RA associations, identifying factors like smoking behavior and hypothyroidism as significant risks. The dataset was last updated on 2026-03-18 and is available under a CC-BY-4.0 license.

Use Cases

• Prioritizing public health interventions based on high-quality evidence for risk factors like smoking behavior.
• Identifying potential drug targets by analyzing nominally protective factors such as Interleukins-1 receptor antagonist.
• Investigating shared disease mechanisms by examining subtype analyses for factors like basal metabolic rate.
• Assessing the quality of genetic evidence in the field by reviewing the proportion of Robust and Probable evidence classifications.

Strengths

• Synthesizes evidence from 117 studies, covering 496 MR associations.
• Meta-analysis performed on 200 exposure-RA associations using a random-effects model.
• Evidence strength is graded, with 7.66% classified as Robust and 26.01% as Probable.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description notes a high proportion of low-quality evidence among the included associations.

Provenance

Source

figshare, author Xu Han.

Collection Method

Systematic review and meta-analysis of published two-sample Mendelian randomization studies.

Freshness

Last updated 2026-03-18 22:01:17.