HIV Vaccine Immune Responses Stratified by CD4/CD8 Ratio

Single-cell RNA sequencing data from peripheral blood mononuclear cells of people living with HIV and healthy controls, collected before and after mRNA vaccination. The dataset includes paired TCR profiling, bulk BCR repertoire analysis, and neutralizing antibody assessments, stratified by CD4/CD8 ratio. Authored by Faith Jessica Paran and last updated on June 1, 2026.

Use Cases

• Analyze differential gene expression patterns based on CD4/CD8 ratio stratification.
• Investigate protein-protein interaction network topology changes in vaccine-induced immune states.
• Study TCR and BCR repertoire clonal skewing and diversity in people living with HIV.
• Correlate monocyte-specific network connectivity with clinical immune markers.

Strengths

• Data includes paired single-cell RNA sequencing and TCR profiling from a controlled study.
• Analysis stratifies participants by a clinically relevant marker (CD4/CD8 ratio).
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 294.4 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Peripheral blood mononuclear cells were collected and analyzed by single-cell RNA sequencing with paired TCR profiling.

Freshness

Last updated 2026-06-01 05:23:04