Single-Cell RNA Sequencing of Vaccine-Induced Immune Responses in People Living with HIV

Peripheral blood mononuclear cell data from people living with HIV and healthy controls, collected before and after mRNA vaccination. The dataset includes single-cell RNA sequencing with paired T-cell receptor profiling, protein-protein interaction network analyses, and neutralizing antibody assessments. It was authored by Faith Jessica Paran and last updated on June 1, 2026.

Use Cases

• Analyzing differential gene expression patterns based on CD4/CD8 ratio stratification mentioned in the description
• Studying protein-protein interaction network topology and monocyte-specific connectivity described in the results
• Investigating T-cell and B-cell receptor repertoire clonality and diversity in the context of vaccination
• Modeling the relationship between immune network reorganization and conventional clinical markers

Strengths

• Includes paired single-cell RNA sequencing and T-cell receptor profiling data
• Contains pre- and post-vaccination time points for longitudinal analysis
• Data is licensed under CC-BY-4.0, permitting open reuse with attribution

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is small at 294.4 KB, indicating limited scope

Provenance

Source

figshare

Collection Method

Peripheral blood mononuclear cells were analyzed by single-cell RNA sequencing with paired TCR profiling, as described in the methods.

Freshness

Last updated 2026-06-01 05:23:04