T Regulatory Cell Extracellular Vesicle Proteomics from Three Subsets

163 common proteins identified in small extracellular vesicles (sEV) from three types of T regulatory cells (Tregs). The dataset, authored by María José Moya-Guzmán and shared on figshare, characterizes sEV production and function from natural and in vitro-induced Treg subsets. It includes proteomic analysis revealing proteins related to Treg biology and cell death pathways.

Use Cases

• Identify candidate proteins for Treg suppression mechanisms based on the 163 common proteins identified.
• Compare functional profiles of extracellular vesicles based on the described subsets: nTregs, iTregs, and RATregs.
• Investigate cell death induction in immune cells based on the described apoptotic effects of Treg-derived sEV.
• Analyze protein clusters related to specific pathways like Granzyme/Perforin based on the proteomic analysis results.

Strengths

• Proteomic analysis identified 163 common proteins across Treg subsets.
• Functional characterization includes suppression assays on CD4+ and CD8+ T cell proliferation.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a 78.7 KB DOCX document, which is a very small and potentially limited data format for structured analysis.

Provenance

Source

figshare

Collection Method

Experimental characterization and proteomic analysis of small extracellular vesicles from T regulatory cell subsets.

Freshness

Last updated 2026-04-21 05:35:34; freshness should be verified.