CD100 and HBcAg-Specific CD8+ T Cell Activation: Transcriptomic and Functional Data

Membrane-bound CD100 deficiency significantly impaired the proliferation, activation, and effector function of Hepatitis B core antigen-specific CD8+ T cells in vitro and in vivo. Transcriptomic analysis revealed downregulation of gene sets associated with PI3K-Akt, mTOR, NF-κB, and JAK-STAT signaling pathways in CD100 knockout cells. The 5.0 MB document by Mengxiao Zhao, last updated in June 2026, presents research data under a CC-BY-4.0 license.

Use Cases

• Analyzing the role of membrane-bound CD100 in T cell co-stimulation based on in vitro proliferation and cytokine production assays.
• Investigating signaling pathway dysregulation in CD100-deficient T cells based on transcriptomic data mentioned in the description.
• Modeling early T cell responses in acute HBV infection based on adoptive transfer experiments with TCR-transgenic cells.

Strengths

• Data is associated with a specific, peer-reviewed research question on a defined immunological mechanism.
• Includes multi-faceted experimental data combining in vitro functional assays, in vivo adoptive transfer, and transcriptomic analysis.
• Dataset is openly licensed under CC-BY-4.0, facilitating reuse.

Limitations

• The primary data format is a DOCX document, which may require extraction and structuring for computational analysis.
• Column-level documentation and sample data are unavailable, limiting immediate assessment of data structure.
• Row count and granular data scale are unknown.

Provenance

Source

figshare, author Mengxiao Zhao.

Collection Method

Generated from laboratory experiments including separate/co-culture systems, adoptive transfer models, and transcriptomic profiling.

Freshness

Last updated 2026-06-03.