Cerebrospinal Fluid Proteomics for Hydrocephalus Candidate Proteins

An exploratory study from 2026 compares cerebrospinal fluid proteomic profiles in post-hemorrhagic hydrocephalus (PHH) and idiopathic normal pressure hydrocephalus (iNPH). The dataset, authored by Hao Han and shared under a CC-BY-4.0 license, contains normalized protein expression values from 11 participants analyzed via Olink proximity extension assay. It identifies calcyphosine (CAPS) and follistatin-like 1 (FSTL1) as exploratory candidate proteins of interest.

Use Cases

• Identify differentially expressed proteins in hydrocephalus subtypes based on proteomic profiles.
• Validate exploratory candidate biomarkers like calcyphosine and follistatin-like 1 in independent cohorts.
• Perform functional annotation analysis using pathways like Gene Ontology, KEGG, and Reactome mentioned in the description.
• Compare protein-abundance patterns between post-hemorrhagic and idiopathic normal pressure hydrocephalus.

Strengths

• Includes data from 11 participants with samples passing quality-control criteria.
• Analysis includes differential expression and multiple functional annotation sources (Gene Ontology, KEGG, Reactome, etc.).
• Key exploratory findings for CAPS and FSTL1 were validated via ELISA in an expanded cohort.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 11.4 KB, indicating limited scope and sample size.

Provenance

Source

figshare, author Hao Han

Collection Method

Cerebrospinal fluid samples analyzed using Olink proximity extension assay proteomics.

Freshness

Last updated 2026-05-29 07:14:56; freshness should be verified.