Table 1_Changes in incretin hormone concentrations after pancreaticoduodenectomy: a system

Oliwia Grząsiak-Kraj's systematic review and exploratory meta-analysis examines changes in glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) after pancreaticoduodenectomy. The work, published on figshare, synthesizes evidence from six human studies involving 134 participants identified from PubMed, Embase, and Scopus between 2000 and 2026. It includes an exploratory meta-analysis comparing two surgical reconstruction techniques.

Use Cases

• Analyzing trends in postprandial GLP-1 and GIP secretion after pancreaticoduodenectomy based on the systematic review findings
• Comparing hormonal outcomes between Whipple and pylorus-preserving pancreaticoduodenectomy based on the exploratory meta-analysis
• Investigating the relationship between gastric emptying, nutrient exposure, and incretin hormone signaling as described in the review results
• Identifying gaps in clinical evidence for future research on incretin hormones after pancreatic surgery as outlined in the conclusions

Strengths

• Follows PRISMA 2020 guidelines for systematic review methodology
• Includes data from six studies with a total of 134 participants
• Registered with PROSPERO (identifier 1345848) for transparency
• Licensed under CC-BY-4.0 for open access and reuse

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download
• Column-level documentation is absent; field semantics must be inferred after download
• The meta-analysis component is explicitly described as exploratory and based on only two studies per comparison

Provenance

Source

figshare

Collection Method

Systematic literature review of PubMed, Embase, and Scopus, followed by an exploratory meta-analysis.

Time Range

Studies published from 1 January 2000 to 27 March 2026

Freshness

Last updated 2026-06-03 12:49:47; freshness should be verified