Circular RNA Expression in Holstein Cow Mammary Tissue Across Perinatal and Dry Periods

Yan Liang's dataset from figshare, last updated May 2026, characterizes circular RNAs (circRNAs) in Holstein cow mammary tissue. It contains 10,388 identified circRNAs, comparing expression between the perinatal and dry physiological periods. The analysis includes differential expression results and functional enrichment pathways.

Use Cases

• Identify differentially expressed circRNAs based on the 132 significant candidates reported between perinatal and dry periods.
• Analyze circRNA genomic features based on reported characteristics like exon count (1-47) and sense-overlapping classification (91.97%).
• Investigate potential roles in immunity and infection based on enriched pathways mentioned, such as cell adhesion molecules and herpesvirus infection.
• Study circRNA distribution across chromosomes based on the reported concentration on chromosome 1 (597 circRNAs).

Strengths

• Contains 10,388 identified circRNAs with specific size range (48 bp to 99,406 bp).
• Reports 132 circRNAs with significantly different expression between periods, with 99 upregulated and 33 downregulated.
• Provides functional enrichment analysis results, linking circRNAs to biological processes like cell differentiation and infection pathways.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Based on a small sample of three cows, which may limit generalizability.

Provenance

Source

figshare, author Yan Liang.

Collection Method

RNA sequencing and bioinformatic analysis of mammary tissue from three Holstein cows.

Time Range

Covers the perinatal and dry physiological periods.

Freshness

Last updated 2026-05 25 22:02:08; freshness should be verified.

Geography

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