Mouse Metabolic Data on Chestnut Extract Intervention Against Western Diet

A study by Maša Skelin Klemen, last updated April 30, 2026, investigated the effects of chestnut-derived ellagitannins (FT50) on metabolic dysfunction in mice. The dataset likely contains body weight, adiposity, glucose tolerance, insulin levels, and pancreatic beta cell activation metrics from C57BL/6J male mice fed a western diet with or without FT50 supplementation for 12 weeks. The 145.6 KB PDF file is licensed under CC-BY-4.0.

Use Cases

• Analyze the relationship between dietary supplementation and body weight gain based on monitored body weight and adiposity.
• Model glucose homeostasis based on fasting glucose levels, insulin levels, and HOMA-IR index measurements.
• Investigate beta cell function dynamics based on ex vivo Ca2+ imaging data describing activation thresholds and network coordination.
• Compare metabolic outcomes between intervention and control groups based on parameters like glucose tolerance and hyperinsulinemia.

Strengths

• Data is derived from a controlled 12-week animal study with defined dietary interventions.
• Includes multiple physiological readouts such as body weight, glucose tolerance, insulin action indices, and ex vivo pancreatic imaging.
• Dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study is limited to early-stage metabolic alterations in male mice and does not address later disease stages or establish direct effects on insulin sensitivity.

Provenance

Source

Maša Skelin Klemen via figshare

Collection Method

Experimental data from a preclinical mouse study where male C57BL/6J mice were fed defined diets for 12 weeks and monitored.

Time Range

The study duration was 12 weeks; specific calendar dates are not provided.

Freshness

Last updated 2026-04-30 11:39:20; freshness should be verified.