Pediatric Glucocorticoid Exposure and Cardiac Outcomes Review Data

Wenxuan Li published a narrative review synthesizing clinical evidence on childhood systemic glucocorticoid exposure and cardiac effects in March 2026. The dataset, shared under CC BY 4.0 on figshare, is a 16.7 KB XLSX file. It compiles evidence on myocardial hypertrophy, subclinical functional alterations, and cardiovascular risk factors from pediatric studies.

Use Cases

• Analyze associations between glucocorticoid exposure timing and myocardial hypertrophy phenotype outcomes.
• Compare evidence for systolic function preservation versus subclinical impairment in metrics like tissue Doppler parameters.
• Examine synthesized data on dose-time associations with intermediate cardiometabolic risk factors.
• Contextualize pathophysiologic pathways mediating pediatric exposure to later cardiovascular disease.

Strengths

• Data is explicitly licensed for reuse under CC BY 4.0.
• Compiles evidence across key pediatric conditions with repeated or prolonged systemic glucocorticoid use.
• Synthesizes findings on multiple outcome types: structural remodeling, functional alterations, and risk factors.

Limitations

• The dataset is very small at 16.7 KB, indicating limited primary data, likely containing only summary tables or extracted findings.
• As a narrative review, the data represents synthesized secondary evidence, not original patient-level records.
• Direct longitudinal data linking pediatric exposure to hard adult outcomes like heart failure is noted as limited within the source material.

Provenance

Source

figshare, authored by Wenxuan Li.

Collection Method

Synthesis of representative clinical evidence from a narrative literature review.

Time Range

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Freshness

Last updated March 2026.

Geography

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