Cardiac Function and Protein Expression in Aged Rat Hearts After Quercetin Treatment

A 674.1 KB DOCX file from figshare contains data from a study on chronic quercetin supplementation in aged male Wistar rats. The study, authored by Jakub Strapec and last updated in April 2026, assessed cardiac function recovery and signaling protein expression following ischemia-reperfusion injury.

Use Cases

• Analyze the effect of quercetin on electrical function parameters like QT intervals based on the described experimental results.
• Investigate the relationship between chronic polyphenol treatment and apoptotic signaling, specifically the Bcl-2/Bax ratio, as indicated in the Western blot analysis.
• Compare recovery outcomes for electrical versus contractile function in aged animal hearts subjected to ischemia-reperfusion.
• Study cardioprotective mechanisms independent of the RISK pathway or autophagy in an aged model, as suggested by the conclusions.

Strengths

• Data is derived from a controlled experimental design with a specific treatment regimen (20 mg/kg/day quercetin for 6 weeks).
• Includes multiple assessment modalities: functional parameters (electrical and mechanical) and molecular analysis (Western blot).
• Focuses on an aged animal model (20-month-old rats), which may have higher translational relevance for human cardiovascular disease.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical analysis.
• The dataset scope is limited to a single species, strain, sex, and age group, which may affect generalizability.

Provenance

Source

figshare, author Jakub Strapec.

Collection Method

Experimental data from Langendorff-perfused isolated rat hearts and Western blot analysis of left ventricular tissue.

Time Range

The experimental timeframe is described, but the data collection date is not explicitly stated.

Freshness

Last updated 2026-04 28 04:29:03; freshness should be verified.

Geography

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