Granzyme A Biomarker Levels in 42 Patients with Abdominal Sepsis

A single-center prospective cohort study of 42 adults with secondary peritonitis and 31 healthy controls, conducted at Lozano Blesa Clinical Hospital in Zaragoza, Spain. The dataset includes serum measurements of Granzyme A concentration and activity, Granzyme B, cytokines, and endothelial and coagulation markers taken at baseline, 24 hours, and 48 hours. It was authored by Galadriel Pellejero-Sagastizabal and last updated on 2026-05-29.

Use Cases

• Modeling associations between baseline Granzyme A levels and in-hospital mortality based on logistic regression analyses described.
• Analyzing temporal dynamics of inflammatory markers like cytokines and endothelial markers across three measurement time points.
• Comparing biomarker profiles, including VCAM-1 and Granzyme B, across Sepsis-3 severity strata (sepsis, septic shock).
• Conducting sensitivity analyses on biomarker-mortality associations after excluding immunosuppressed patient subgroups.

Strengths

• Includes longitudinal biomarker measurements from 42 patients across three time points (baseline, 24h, 48h).
• Provides specific statistical results, such as a 2.3-fold increase in GzmA concentration (q-value = 5.41×10^−12) and an odds ratio of 2.52 for mortality.
• Dataset is licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• Data is from a single-center study with 42 patients, which may limit generalizability.
• The primary data file is a DOCX document (1.9 MB), which may require extraction to access structured data.

Provenance

Source

figshare, authored by Galadriel Pellejero-Sagastizabal.

Collection Method

Single-center prospective cohort study with blood sample analysis.

Time Range

The study period is not specified, but data includes measurements at baseline, 24h, and 48h.

Freshness

Last updated 2026-05-29 04:46:53; freshness should be verified.

Geography

Data collected from Lozano Blesa Clinical Hospital in Zaragoza, Spain.