Clinical and Ultrasound Features for Bethesda III/IV Thyroid Nodule Risk Stratification

A single-center retrospective cohort study of 206 adult patients with Bethesda III or IV thyroid nodules, authored by Junmei Wang and last updated in May 2026. The dataset includes clinical characteristics, biochemical parameters, and standardized ultrasound features, with malignancy confirmed by surgical histopathology or a composite reference standard. It was used to develop an optimized post-fine-needle aspiration management pathway.

Use Cases

• Training a binary classification model to predict malignancy based on clinical and ultrasound features like free thyroxine levels and nodule shape.
• Developing a clinical decision support tool that integrates multivariable predictors such as marked hypoechogenicity and suspicious cervical lymph nodes.
• Evaluating the diagnostic yield of repeat fine-needle aspiration procedures for cytologic reclassification.
• Conducting decision curve analysis to compare the net clinical benefit of different management pathways.

Strengths

• Dataset includes 206 patient records with confirmed malignancy outcomes for 87 nodules (42.2%).
• Multivariable model demonstrated good discrimination with an optimism-corrected AUC of 0.798.
• Analysis includes specific, actionable predictors like taller-than-wide shape (OR 3.69) and punctate echogenic foci (OR 2.01).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect single-center bias inherent to the study design on figshare.

Provenance

Source

Junmei Wang via figshare.

Collection Method

Retrospective cohort study extracting data from patient records.

Freshness

Last updated 2026-05-21 04:37:35; freshness should be verified.