Table 1_Clinical efficacy of immunotherapy in combination of locoregional therapies for ad

Xinyue Chen's meta-analysis, published on figshare in March 2026, synthesizes results from 19 cohort studies involving 3,720 patients with advanced hepatocellular carcinoma. It compares clinical outcomes such as overall survival and progression-free survival between patients receiving locoregional therapies alone versus those receiving combined immunotherapy and locoregional therapies. The document reports pooled hazard ratios and odds ratios for efficacy and adverse events.

Use Cases

• Compare overall survival (OS) and progression-free survival (PFS) outcomes between treatment groups based on the reported hazard ratios.
• Assess treatment efficacy via objective response rate (ORR) and disease control rate (DCR) metrics from the meta-analysis.
• Evaluate the risk of adverse events (AEs), including specific immune-related events like pneumonitis and myocarditis, associated with combined therapy.
• Perform secondary analysis or validation of the pooled results for the 19 included cohort studies.

Strengths

• Analysis is based on 19 cohort studies encompassing 3,720 patients, providing a substantial evidence base.
• Reports specific statistical results, including hazard ratios with 95% confidence intervals for OS (HR=0.36) and PFS (HR=0.41).
• Includes a systematic review registration identifier (CRD420251039316) and details the search methodology across major databases.

Limitations

• The dataset is a 139.7 KB DOCX file containing a manuscript, not a structured data table; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.
• The data is a static meta-analysis snapshot; clinical guidelines and new trials may supersede its conclusions over time.

Provenance

Source

figshare, author Xinyue Chen.

Collection Method

Systematic review and meta-analysis of studies from Embase, PubMed, Cochrane Library, and Web of Science.

Time Range

Temporal coverage of the included studies is not specified.

Freshness

Last updated 2026-03-18 07:41:50.

Geography

Spatial coverage of the included studies is not specified.