ALDH1L1 Expression and Survival in Hormone Receptor-Positive Breast Cancer

South Korean clinical data from Seoul National University Hospital analyzed ALDH1L1 expression across 1,086 breast cancer cases. The research combined three cohorts, including a tissue microarray of 1,001 invasive ductal carcinoma patients, to assess correlations with tumor aggressiveness and survival. Han Suk Ryu published the findings on figshare in 2026 under a CC-BY-4.0 license.

Use Cases

• Prognostic modeling based on ALDH1L1 expression levels mentioned in the description
• Subtype-specific survival analysis based on hormone receptor status
• Investigating associations between folate metabolism and tumor aggressiveness based on described clinicopathologic features

Strengths

• Analysis includes a combined sample of 1,086 cases from three distinct cohorts
• Clinical data includes tumor size, grade, lymphatic invasion, and lymph node metastasis
• Findings were validated using the external METABRIC database

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect geographic bias inherent to a single hospital source

Provenance

Source

Seoul National University Hospital

Collection Method

Immunostaining performed on tissue microarrays and whole section slides; clinical data collected from patient records.

Freshness

Last updated 2026-05-25 04:33:59; freshness should be verified

Geography

South Korea