Clinical Data on Malnutrition in Huntington's Disease from a Chinese Cohort

A cohort study contains data from 113 genetically confirmed Huntington's disease patients and 113 matched healthy controls. It includes nutritional assessments using CONUT, GNRI, and PNI scores, clinical evaluations from UHDRS, cognitive, and psychiatric tests, and longitudinal outcomes over a mean 5.74-year follow-up. Mendelian randomization analysis explores causal links between nutritional indicators and disease progression.

Use Cases

• Correlate CONUT, GNRI, and PNI nutritional scores with Unified Huntington's Disease Rating Scale (UHDRS) and cognitive test results to identify predictors of functional decline.
• Apply survival analysis using Kaplan-Meier and Cox regression on the composite endpoint (death or TFC ≤ 2) to assess the prognostic value of malnutrition indicators.
• Validate Mendelian randomization findings by analyzing the relationship between lymphocyte count data and motor progression metrics within the cohort.
• Compare malnutrition prevalence rates (e.g., CONUT: 34.51% vs. 13.27%) between the patient and healthy control groups to quantify disease-associated metabolic disturbance.

Strengths

• Includes a matched case-control design with 113 patients and 113 healthy controls for comparative analysis.
• Provides longitudinal data with a mean follow-up period of 5.74 years and tracks 44 composite endpoint events.
• Assesses nutritional status using three validated scoring systems: CONUT, GNRI, and PNI.
• Integrates clinical data from multiple domains including UHDRS, cognitive tests, and psychiatric assessments.

Limitations

• The cohort size of 113 patients is relatively small for robust multivariate or subgroup analyses.
• Data is geographically limited to a Chinese population, which may limit generalizability to other ethnic groups.
• Primary data is embedded in a DOCX document, requiring manual extraction for computational analysis.

Provenance

Source

figshare, authored by Jie-Qiang Xia.

Collection Method

Cohort study with clinical assessments and Mendelian randomization analysis using GWAS data.

Time Range

Study period includes a mean follow-up of 5.74 years; specific start year not provided.

Freshness

Last updated in March 2026.

Geography

Chinese patient cohort.