Table 1_Clinical significance and simultaneous microevolution of two closely-related nontuberculous mycobacteria species.docx

A 2026 single-case study by Chengcheng Wang details a pulmonary co-infection of two nontuberculous mycobacteria species. The research includes clinical data, microbiological assays, genome sequencing of 20 colonies per species, and virulence testing using Galleria mellonella larvae. It also incorporates a literature review of 19 additional M. septicum cases and re-analysis of 16 publicly accessible genomes.

Use Cases

• Analyze clinical significance data to classify M. septicum instances as pathogen, colonizer, or contaminant.
• Study genomic heterogeneity by comparing sequences from 20 colonies each of M. septicum and M. nivoides.
• Investigate putative microevolution trajectories via specific gene variations like α/β hydrolase or papA2 mutations.
• Correlate identified genetic mutations with enhanced virulence metrics from the Galleria mellonella model.
• Validate genome classification by re-analyzing the 16 publicly accessible genomes for potential mislabeling of M. nivoides.

Strengths

• Includes genome sequencing data for 20 bacterial colonies per species from a single patient.
• Integrates multiple data types: clinical records, genomic sequences, and experimental virulence assays.
• Literature review summarizes 19 additional clinical cases of M. septicum.
• Re-analyzes 16 publicly accessible bacterial genomes for taxonomic accuracy.

Limitations

• Primary clinical and genomic data is derived from a single-case study, limiting statistical power.
• The 8.0 MB file size suggests the dataset is primarily a document, not a large-scale structured data table.
• Row counts and specific column names for structured data are not provided.

Provenance

Source

figshare, authored by Chengcheng Wang.

Collection Method

Single-case study combining clinical data, microbiological assays, genome sequencing, virulence testing, and literature review.

Time Range

Study published in 2026; temporal coverage of clinical case and literature review not specified.

Freshness

Last updated in April 2026.

Geography

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