Cocaine-Induced m6A RNA Modifications and Locomotor Plasticity in Drosophila

Ana Filošević Vujnović's dataset from a 2026 figshare publication investigates how cocaine exposure remodels N6-methyladenosine (m6A) RNA modifications in Drosophila melanogaster. It integrates RNA-seq and MeRIP-seq data to show cocaine's selective amplification of m6A in regulatory and plasticity-associated RNA classes. The 59.2 KB XLSX file links these epitranscriptomic changes to m6A reader-dependent behavioral plasticity.

Use Cases

• Analyze cocaine-induced changes in global m6A levels based on total and poly(A)-enriched RNA measurements
• Investigate the role of m6A readers (YTHDC, YTHDF) in locomotor sensitization based on genetic and cell-type-specific analyses
• Identify m6A-modified RNA classes, such as antisense RNAs and transposable elements, that are selectively amplified by cocaine exposure
• Compare m6A modification patterns between control and cocaine-exposed conditions for core metabolic pathways like oxidative phosphorylation

Strengths

• Data integrates multiple experimental modalities: RNA-seq, MeRIP-seq, and behavioral sensitization assays
• Includes cell-type-specific genetic analyses of m6A writers and readers in neurons and glia
• Released under a permissive CC-BY-4.0 license for reuse

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download
• Dataset is small (59.2 KB), indicating limited scope, likely containing summary or key results rather than raw sequencing data

Provenance

Source

Ana Filošević Vujnović via figshare

Collection Method

Experimental data from Drosophila melanogaster exposed to volatilized cocaine, analyzed via RNA-seq and MeRIP-seq.

Time Range

Experimental timeframe not specified in metadata.

Freshness

Last updated 2026-04-15 04:37:04

Geography

Laboratory study; geographic coverage not applicable.