Codon Deoptimization Effects on Multispecific Antibody Purity and Yield

Experimental data from a study investigating the impact of rare serine codon insertion on multispecific antibody expression. The dataset likely contains measurements of protein purity, yield, and mispaired species for trispecific and bispecific antibodies. Timothy Z. Chang authored this work, which was last updated on March 18, 2026.

Use Cases

• Modeling the relationship between codon usage and protein purity based on the described negative correlation.
• Training predictive models for mispaired species formation in multispecific antibodies based on codon sequence features.
• Benchmarking expression optimization strategies for bispecific and trispecific antibody formats mentioned in the description.

Strengths

• Data is associated with a detailed scientific methodology described in the input.
• File size is 633.7 KB, indicating a focused and likely manageable dataset.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data scope is limited to a specific experimental study on serine codon deoptimization.

Provenance

Source

figshare

Collection Method

Experimental results from transient mammalian protein expression studies.

Freshness

Last updated 2026-03-18 07:46:15; freshness should be verified.