Cognitive Dysfunction and Lung Transcriptomics in Interstitial Lung Disease

A study of 45 interstitial lung disease (ILD) patients and 45 age-matched controls, comparing cognitive status via Mini-Mental State Examination scores and lung tissue transcriptomic data from 139 RNA-seq samples. The analysis links cognitive impairment in ILD patients to lung tissue gene expression patterns, including differential expression of 1,544 genes and examination of Alzheimer's-related genes like PSEN1 and BACE1.

Use Cases

• Correlate Mini-Mental State Examination total and subscale scores with patient pulmonary function characteristics.
• Analyze differential expression of 1,544 genes, including PSEN1 and BACE1, between ILD cases and non-diseased controls.
• Investigate Gene Ontology enrichment for nervous system function pathways within lung tissue transcriptomic data.
• Compare expression trends of Alzheimer's-related genes (PSEN1, PSEN2, BACE1, MME) across idiopathic pulmonary fibrosis and non-IPF subgroups.

Strengths

• Includes matched clinical and transcriptomic data from 45 ILD patients and 45 controls.
• Lung tissue RNA-seq analysis covers 139 samples from 29 ILD cases and 14 controls.
• Differential expression analysis identified 1,544 genes with a |log2FC| > 1 and FDR < 0.05.

Limitations

• Small clinical cohort size of 90 total participants limits statistical power for subgroup analyses.
• Cross-sectional design prevents establishing causal links between lung transcriptomics and cognitive dysfunction.
• Transcriptomic data is from a separate cohort (GSE213001), not directly paired with all clinical cognitive assessments.

Provenance

Source

figshare, authored by Xiaojun Deng.

Collection Method

Clinical cohort study combined with secondary analysis of public RNA-seq dataset GSE213001.

Time Range

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Geography

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