SLE Biomarkers for Anti-dsDNA Stratification: 126 Patient Records

126 patients with systemic lupus erythematosus (SLE) were enrolled in a study by Chaoju Yang, with data last updated in April 2026. The dataset likely contains clinical and laboratory parameters used to assess relationships between biomarkers and anti-dsDNA antibody status. It includes measurements of 25-hydroxyvitamin D, CD4+/CD8+ ratio, and prognostic nutritional index.

Use Cases

• Predicting anti-dsDNA antibody serostatus based on levels of 25(OH)D, CD4+/CD8+ ratio, and PNI.
• Stratifying patients into low-positive and high-positive anti-dsDNA titer groups using the combined biomarker assessment.
• Evaluating the discriminatory performance of individual and combined biomarkers via ROC curve analysis.
• Investigating associations between biomarker levels and clinical outcomes like renal involvement.

Strengths

• Data is based on a cohort of 126 patients with SLE.
• Includes specific biomarker measurements: 25(OH)D, CD4+/CD8+ ratio, and PNI.
• Results include ROC analysis comparing discriminatory performance of biomarkers.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The study's conclusions are described as exploratory and require external validation.

Provenance

Source

figshare

Collection Method

Clinical study enrolling patients with SLE and comparing laboratory parameters.

Freshness

Last updated 2026-04-29 05:37:21; freshness should be verified.