Mouse Gut Microbiota and Injury Markers Under Combined Heat and Exercise Stress

A figshare-hosted dataset by Leizi Min, last updated in May 2026, containing results from a study on exertional heat stroke in mice. The data likely includes measurements of intestinal injury, circulating D-lactate levels, and 16S rRNA gene sequencing profiles from gut and blood samples. It compares microbial and physiological responses across Control, Exercise, Heat shock, and combined Exercise + Heat shock groups.

Use Cases

• Analyzing associations between intestinal injury markers and circulating microbial profiles based on correlation analyses mentioned in the description.
• Comparing taxonomic profiles and microbial diversity changes associated with heat, exercise, and their combination based on differential abundance analyses.
• Investigating the distinct contributions of heat exposure and physical exercise to gut microbial community structure and barrier function.
• Modeling systemic detection of gut-derived microbial signatures as a response to physiological stressors.

Strengths

• Data is derived from a controlled experimental design with four distinct intervention groups (Control, Exercise, Heat shock, Exercise + Heat shock).
• Includes multiple data modalities: histopathology, circulating biomarker (D-lactate) levels, and 16S rRNA gene sequencing profiles from two sample types (gut and blood).
• Released under a permissive CC-BY-4.0 license, facilitating reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment; the file size of 11.5 KB suggests a very limited scope.
• The dataset is based on a mouse model (C57BL/6 mice), which may limit direct translation to human physiology.

Provenance

Source

figshare

Collection Method

Experimental data from male C57BL/6 mice subjected to exercise and/or heat exposure, with subsequent analysis of intestinal injury, permeability, and 16S rRNA gene sequencing.

Freshness

Last updated 2026-05-25 06:07:54; freshness should be verified.