Table 1_Combined single-cell transcriptome and Mendelian randomization to identify and val

Seven prognostic genes associated with endoplasmic reticulum stress and butyrate metabolism in lung adenocarcinoma were identified and validated. The dataset includes results from a risk model, nomogram, and immune microenvironment analysis, validated by RT-qPCR in non-small cell lung cancer cell lines. Author Jiaxin Li published the data on figshare in March 2026 under a CC-BY-4.0 license.

Use Cases

• Building a prognostic risk model for lung adenocarcinoma based on the seven identified genes (VDAC1, TXNRD1, GDF15, TRIB3, LPL, KCNQ1, PKP2).
• Analyzing immune cell type abundance in the tumor microenvironment based on the 13 differentially abundant immune cell types mentioned.
• Investigating pathway enrichment differences between high-risk and low-risk patient groups, such as olfactory transduction or ribosome pathways.
• Validating gene expression patterns in macrophage differentiation using the single-cell analysis results for VDAC1, TXNRD1, and LPL.

Strengths

• Includes seven validated prognostic genes confirmed by RT-qPCR assays in different NSCLC cell lines.
• Risk model and nomogram demonstrated predictive accuracy for 1-, 3-, and 5-year survival outcomes.
• Analysis integrated multiple public datasets and methods, including single-cell transcriptomics and Mendelian randomization.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 30.4 KB, indicating limited scope, likely containing summary results rather than raw data.
• Data may reflect bias inherent to the specific public datasets and analytical methods used in the original study.

Provenance

Source

figshare, author Jiaxin Li.

Collection Method

Integrated analysis of public datasets using weighted gene co-expression network analysis, differential expression analysis, and Mendelian randomization.

Freshness

Last updated 2026-03-25 22:03:00; freshness should be verified.