Comparative DCMS Analysis of X-linked Selection Signatures in Changthangi Sheep

A genomic dataset presents results from a de-correlated composite of multiple signals (DCMS) analysis on the X chromosome in three indigenous Indian sheep breeds. The analysis identified a significant breed-specific genomic region in Changthangi sheep, annotated candidate genes and quantitative trait loci, and prioritized genes via protein-protein interaction networks. Saptha Nath authored the dataset, which was last updated on 2026-05-18.

Use Cases

• Identify candidate genes for local adaptation in high-altitude sheep based on the described X-linked selection signature.
• Compare selection signals across breeds based on the DCMS analysis of Changthangi, Deccani, and Garole sheep.
• Prioritize genes for traits like milk production and body weight based on the QTL enrichment results.
• Validate composite statistical approaches for X chromosome analysis in indigenous populations based on the study's methodology.

Strengths

• The dataset is derived from 79 sheep samples genotyped with the Illumina OvineSNP50 BeadChip.
• Analysis identified a specific genomic region (~1.396 Mb) on the X chromosome in Changthangi sheep.
• Results include annotation of 31 candidate genes and prioritization of OTUD5, CACNA1F, ZNF182, and GRIPAP1.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (176.3 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Genomic analysis using a DCMS approach integrating FST, H1, H12, Tajima's D, and π statistics.

Freshness

Last updated 2026-05-18 22:02:39; freshness should be verified.

Geography

India (focus on indigenous Changthangi, Deccani, and Garole sheep breeds)