Comparative Efficacy and Adverse Events of Pediatric Sedation Regimens: A Randomized Trial

180 children aged 1–6 years were enrolled in a single-center randomized controlled trial comparing two sedation regimens. The trial, conducted between December 2022 and October 2023, measured first-attempt sedation success, peri-sedation events, and caregiver-reported adverse events within 48 hours post-discharge. Author Haisu Li published the results under a CC-BY-4.0 license on figshare.

Use Cases

• Compare first-attempt sedation success rates between dexmedetomidine-midazolam and dexmedetomidine-chloral hydrate regimens.
• Analyze the incidence and clustering of post-discharge adverse events like somnolence and ataxia.
• Evaluate factors influencing parental satisfaction and children's medication acceptance during procedural sedation.
• Model independent risk factors for post-discharge behavioral changes using multivariable analysis results.

Strengths

• Data originates from a prospective, randomized controlled trial, a robust study design.
• Includes 180 patient records with clearly defined primary and secondary outcome measures.
• Captures detailed temporal data, including sedation onset time, recovery time, and a 48-hour post-discharge monitoring period.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a single-center trial, which may limit generalizability.

Provenance

Source

figshare

Collection Method

Single-center, prospective, randomized controlled trial.

Time Range

December 2022 to October 2023

Freshness

Last updated 2026-04-24 13:11:54; freshness should be verified.

Geography

Single-center location, not specified.