Campylobacter Jejuni Immunoproteomics in Acute and Asymptomatic Infections

Fernando A. Gómez published a study on 2026-05-28 comparing the human antibody response to Campylobacter jejuni proteins. The work identifies 418 immunoreactive proteins in patients with acute campylobacteriosis and 517 in asymptomatic individuals, revealing differences in recognized protein functions. The dataset is hosted on figshare under a CC-BY-4.0 license.

Use Cases

• Identify candidate virulence-associated antigens based on differential immune recognition between symptomatic and asymptomatic groups.
• Analyze functional enrichment of immunoreactive proteins involved in stress response, motility, and secretion.
• Predict secreted virulence factors based on bioinformatic analysis of C-terminal acidic motifs.
• Compare core versus infection-specific immunoproteomes using the shared and unique protein sets.

Strengths

• Identifies 418 and 517 immunoreactive proteins in two distinct clinical groups, providing a quantitative comparison.
• Functional annotation reveals specific protein categories (e.g., metabolic enzymes, ribosomal proteins, virulence factors) targeted by the immune response.
• Uses a defined immunoproteomic methodology involving immunocapture and nano-liquid chromatography–tandem mass spectrometry.

Limitations

• Dataset scale is limited to a 50.1 KB DOCX file; row and column counts are unknown.
• Column-level documentation is absent; field semantics must be inferred after download.
• The approach does not directly demonstrate secretion, surface exposure, or translocation of the predicted proteins.

Provenance

Source

figshare

Collection Method

Immunocapture of bacterial proteins from human sera followed by nano-liquid chromatography–tandem mass spectrometry.

Freshness

Last updated 2026-05-28 04:51:17; freshness should be verified.