C5aR1 Antagonist Effects on Pulmonary Hypoperfusion-Induced Alveolar Hypoplasia in Rats

A research document details a study on the role of complement component C5a in pulmonary hypoperfusion-induced alveolar hypoplasia. The study uses bulk and single-cell RNA sequencing of lung tissues from neonatal rats and includes histological assessments and serum measurements from children. The document was authored by Chenxi Liu and last updated on 2026-05-11.

Use Cases

• Study the complement cascade pathway in sterile inflammation based on RNA-sequencing results.
• Investigate the C5a–IL-1β–NF-κB–SEMA3a signaling axis in alveolar development based on mechanistic findings.
• Evaluate the therapeutic potential of C5aR1 antagonists for lung conditions based on experimental treatment outcomes.
• Analyze cell-type-specific gene expression in lung monocytes/macrophages based on single-cell RNA sequencing data.

Strengths

• The study integrates multiple experimental methods, including bulk RNA-seq, single-cell RNA-seq, and histological assessment.
• Mechanistic findings are supported by targeted interventions with a C5aR1 antagonist and IL-1β inhibitors.
• Includes a translational component with serum C5a level measurements in children.

Limitations

• The dataset is a 17.0 KB DOCX file, suggesting limited raw data is included directly.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Experimental study involving pulmonary artery banding in rats, RNA sequencing, and histological analysis.

Freshness

Last updated 2026-05-11 04:17:19; freshness should be verified.