BRCA1/2 Mutation Landscape in Prostate Cancer Patients from the UAE and Arab Population

47.5% of 40 analyzed prostate tissue samples from UAE and Arab patients harbored BRCA1 mutations, while 55% had BRCA2 mutations. This dataset, created by Zainab M. Al Shareef and last updated in 2026, presents a retrospective analysis of archived tissues from 2011 to 2022. It details mutation prevalence, zygosity, and novel variants linked to aggressive, high-grade prostate cancer.

Use Cases

• Assess hereditary prostate cancer risk based on BRCA1/2 mutation prevalence and zygosity data
• Identify population-specific genetic variants for ethnicity-informed screening protocols based on novel variant clusters
• Investigate associations between homozygous mutations and disease aggressiveness based on enrichment in high-grade tumors
• Support research into molecularly targeted therapies like PARP inhibitors based on mutation patterns

Strengths

• Mutation prevalence is quantified with specific percentages (e.g., BRCA1 47.5%, BRCA2 55%).
• Clinical context is provided with sample details (40 tissues, 23 PCa, 17 BPH) and a defined time range (2011-2022).
• Variants are classified using established ACMG/AMP criteria and referenced against ClinVar and Varchat.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset's 136.9 KB size indicates a very limited sample scope of 40 tissue specimens.

Provenance

Source

Zainab M. Al Shareef via figshare

Collection Method

Retrospective analysis of 40 archived formalin-fixed, paraffin-embedded prostate tissues with targeted exon sequencing.

Time Range

2011–2022

Freshness

Last updated 2026-05-26 05:25:52; freshness should be verified.

Geography

United Arab Emirates and Arab population