Rectal Cancer Alternative Splicing and Immune Profiles for Vaccine Design

Table 1_Comprehensive profiling of alternative splicing and immune landscapes in rectal cancer: implications for mRNA vaccine design and immune subtype stratification.xls is a 10.0 MB Excel file from figshare, authored by Jiawen Weng and last updated in April 2026. The dataset contains bioinformatics analysis results from TCGA-READ, identifying potential tumor antigens and immune subtypes. It is licensed under CC-BY-4.0.

Use Cases

• Prioritizing candidate tumor antigens for mRNA vaccine design based on upregulated alternative splicing events and frameshift mutations.
• Stratifying rectal cancer patients into immune subtypes (C1/C2) to predict response to immune checkpoint blockade therapies like CTLA-4/PD-1 inhibitors.
• Analyzing correlations between specific antigen genes (e.g., FAM135A) and immune cell infiltration profiles.
• Investigating the prevalence of alternative splicing event types (e.g., exon skipping, mutually exclusive exons) in rectal adenocarcinoma.

Strengths

• Identifies 217 potential antigen genes from intersecting upregulated alternative splicing anomalies and frameshift mutations.
• Highlights specific candidate antigens (FAM135A, GAR1, CDIPT) with FAM135A showing significant correlation with immune cell infiltration.
• Provides a clear immune subtype stratification (C1 and C2) with differential predicted benefit from immunotherapy.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is derived from a single cancer type (TCGA-READ), limiting generalizability.

Provenance

Source

The Cancer Genome Atlas Rectal Adenocarcinoma (TCGA-READ) public data.

Collection Method

Public data analysis using bioinformatics methods.

Time Range

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Freshness

Last updated 2026-04-13 04:35:34; freshness should be verified.

Geography

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