Connexin 43 Expression and Liver Metastasis Potential in GIST Cells

Experimental data from a study investigating the role of Connexin 43 (Cx43) in the metastatic potential of gastrointestinal stromal tumor (GIST) cells. The dataset likely contains results from in vivo liver metastasis xenograft mouse models and in vitro assays comparing GIST-T1 cells with engineered GIST-T1-Cx43 cells. It was authored by Takako Kihara, shared under a CC-BY-4.0 license, and last updated on 2026-06-04.

Use Cases

• Analyze the correlation between Cx43 expression and metastatic potential in GIST cells based on the in vivo liver metastasis model results.
• Compare in vitro cell behaviors such as proliferation, migration, and invasion between cell lines with differential Cx43 expression.
• Investigate the role of tumor-endothelial cell adhesion and transendothelial migration in metastasis based on the described assay results.
• Evaluate Cx43 as a potential therapeutic target for inhibiting metastasis in small intestinal GISTs.

Strengths

• Data is derived from a controlled experimental design comparing original and engineered cell lines.
• Results are supported by statistical significance values (e.g., p = 0.010 for enhanced liver metastasis).
• The dataset is shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is very small at 15.6 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Generated from laboratory experiments using a liver metastasis xenograft mouse model and in vitro assays.

Freshness

Last updated 2026-06-04 05:01:07; freshness should be verified.