Occupational Exposure Limits for 86 Small Molecule Kinase Inhibitors

Tyler Nicholas compiled health hazard data for 86 FDA-approved small molecule kinase inhibitors (SMKIs) to estimate occupational exposure limits (OELs). The dataset includes information on genotoxicity, carcinogenicity, developmental and reproductive toxicity, and therapeutic dose, with OELs ranging from 0.05 to 96 µg/m³. It was last updated on March 25, 2026.

Use Cases

• Assigning occupational exposure bands (OEBs) based on estimated OELs and target family data.
• Prioritizing protective measures for specific kinase inhibitor target families like JAK, FGFR, and MEK.
• Informing risk management frameworks for drug development in data-limited settings using the provided quantitative approach.
• Benchmarking new SMKIs against the hazard profiles of 86 approved drugs.

Strengths

• Includes data for 86 FDA-approved small molecule kinase inhibitors.
• Provides a quantitative framework with estimated OELs ranging from 0.05 to 96 µg/m³.
• Covers multiple hazard endpoints including genotoxicity, carcinogenicity, and developmental toxicity.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is specific to orally administered SMKIs (n=83) and may not cover all administration routes.

Provenance

Source

Tyler Nicholas via figshare.

Collection Method

Data compiled from literature sources and drug labels, with OELs estimated using a standardized dose-based approach.

Freshness

Last updated 2026-03-25 22:01:23; freshness should be verified.