Oxytocin Gene-Alcohol Dependence Interaction Study on Anxiety in Chinese Males

A study of 414 Chinese Han male adults undergoing acute alcohol withdrawal. It examines the interaction between oxytocin gene polymorphisms and alcohol dependence on anxiety and depression symptoms, considering social and environmental contexts. The dataset includes genotyping results, self-reported psychological measures, and demographic information.

Use Cases

• Analyzing gene-environment interactions on anxiety based on oxytocin polymorphisms and alcohol dependence severity.
• Investigating the moderating role of social context (e.g., marital/family status) on genetic risk for negative emotions.
• Studying the relationship between alcohol dependence severity and symptoms of depression and anxiety in a clinical population.
• Examining the weak diathesis-stress model in the context of acute alcohol withdrawal.

Strengths

• Includes data from 414 participants, providing a substantial sample size for analysis.
• Contains multiple data types: genetic (OXT polymorphisms), clinical (alcohol dependence severity), and psychological (anxiety/depression scores).
• Explicitly considers environmental and social context variables (living with family, marital status).

Limitations

• Dataset is very small (35.3 KB), indicating limited scope and likely summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The sample is restricted to Chinese Han male adults, limiting generalizability.

Provenance

Source

Author: Zeping Xu. Platform: figshare.

Collection Method

Participants provided blood samples for genotyping and completed self-reported measures of depression, anxiety, alcohol dependence severity, and demographics.

Freshness

Last updated 2026-05-15 05:28:05; freshness should be verified.

Geography

Chinese Han male adults.