ART Effects on Alveolar Macrophages: Senescence and Interferon Signaling

A systems immunology analysis reveals continuous antiretroviral therapy induces a progressive, senescence-like pro-inflammatory state in alveolar macrophages. The dataset likely contains results linking ART duration to epigenetic and transcriptomic changes, independent of HIV infection. Vinicius M. Fava published this research on figshare in April 2026.

Use Cases

• Modeling the relationship between ART duration and senescence-like gene expression based on the described progressive changes.
• Analyzing gene regulatory networks linking pro-inflammatory transcription factors to ART-induced alterations mentioned in the results.
• Investigating the impact of ART on interferon signaling and SARS-CoV-2 response impairment described in the study.

Strengths

• Data is derived from a systems immunology approach evaluating alveolar macrophages from people with HIV and on PrEP.
• Findings are linked to specific biological states: senescence-like reprogramming and impaired interferon response.
• Dataset is openly licensed under CC-BY-4.0, permitting reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small (17.0 KB), indicating limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

figshare

Collection Method

Likely contains processed results from a systems immunology evaluation of alveolar macrophages using single-nucleus analysis.

Freshness

Last updated 2026-04-22 05:49:14; freshness should be verified.