Meta-Analysis of S. Aureus Colonization and Atopic Dermatitis Severity

A systematic review and meta-analysis of seven randomized controlled trials with 929 participants, conducted by Ruyi Jin and last updated in May 2026. It pools correlation coefficients from studies up to July 2025 to assess the relationship between Staphylococcus aureus colonization and atopic dermatitis severity. The analysis found a moderate positive correlation (r = 0.42) with moderate heterogeneity.

Use Cases

• Validate the association between bacterial colonization and disease severity based on the pooled correlation coefficient.
• Inform clinical trial design for atopic dermatitis treatments based on the systematic review's findings.
• Benchmark new observational studies against the meta-analytic effect size (r = 0.42).
• Conduct sensitivity or subgroup analyses based on the methodological framework described.

Strengths

• Includes data from 7 randomized controlled trials, a study design that suggests controlled data.
• Reports a specific pooled correlation coefficient (r = 0.42) with a 95% confidence interval (0.31–0.52).
• Quantifies heterogeneity with an I² statistic of 38%.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (269.9 KB), indicating limited raw data scope.

Provenance

Source

Ruyi Jin via figshare.

Collection Method

Systematic review and meta-analysis of RCTs from PubMed, Embase, Cochrane Library, and Web of Science.

Time Range

Studies included up to July 19, 2025.

Freshness

Last updated 2026-05-07 04:45:11; freshness should be verified.