Table 1_CORSA study finds spike-specific blunted immune responses in lymphoma patients aft

77 patients with hematological malignancies receiving active treatment were compared to matched healthy controls for humoral and cellular vaccine responses. Seroconversion occurred in only 8% and 21% of patients after the first and second vaccine dose, versus 93% and 100% of controls. The dataset, authored by Lucia Mazzotti and last updated in May 2026, includes measurements of Spike-specific IgG titers, T-cell ELISpot assays, and T-cell receptor repertoire sequencing from baseline to six months post-vaccination.

Use Cases

• Modeling the relationship between antibody titers and T-cell activity in seronegative patients based on the described humoral and cellular response measurements.
• Analyzing clonal breadth and depth of Spike-specific T-cell receptor clones over time based on the TCR repertoire sequencing data.
• Comparing vaccine-induced immune response trajectories between lymphoma patients and healthy controls based on the longitudinal study design.
• Investigating the impact of treatments like Rituximab on vaccine efficacy based on the patient cohort description.

Strengths

• Includes a matched control group of healthy individuals for direct comparison.
• Longitudinal design with measurements from baseline to six months post-vaccination.
• Combines multiple immune response assays: IgG titers, T-cell ELISpot, and TCR sequencing.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 1.0 MB file size suggests a relatively small dataset, potentially limiting statistical power for some analyses.

Provenance

Source

figshare

Collection Method

Data from the CORSA trial, evaluating humoral and cellular responses to mRNA vaccines in patients with hematological malignancies.

Time Range

From baseline to six months after vaccination.

Freshness

Last updated 2026-05-20 05:58:02; freshness should be verified.

Geography

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