Systematic Review on Hippo-YAP and EMT Crosstalk in Oral Cancer Progression

A systematic review synthesizing evidence from 12 studies (26 datasets) on the role of Hippo-YAP signaling and epithelial-mesenchymal transition (EMT) in oral cancer development. The review, authored by Kimia Sadat Kazemi and published on figshare in 2026, followed PRISMA 2020 guidelines and searched five electronic databases. It identifies key molecular interactions and potential biomarkers associated with the malignant transformation of oral potentially malignant disorders to oral squamous cell carcinoma.

Use Cases

• Identify potential prognostic biomarkers for oral cancer based on the review's findings on YAP, hTERT, circEPSTI1, SNAI2, and KLK6 expression.
• Investigate molecular crosstalk between the Hippo-YAP pathway and other signaling cascades (e.g., MAPK/ERK, PI3K/Akt/mTOR, Wnt/β-catenin) in cancer progression.
• Evaluate the utility of YAP-centered EMT regulation as a therapeutic target for chemoprevention and early intervention in oral potentially malignant disorders.

Strengths

• The review is based on a systematic search of five major databases (PubMed, Web of Science, Scopus, LIVIVO, Embase), following PRISMA 2020 guidelines.
• It synthesizes evidence from 12 studies comprising 26 datasets, providing a consolidated view of the field.
• Risk of bias was assessed using established tools (QUIN, SYRCLE, JBI), indicating a structured quality assessment.

Limitations

• The dataset is a 23.6 KB DOCX document, which is a textual summary rather than raw, structured research data.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• Column-level documentation is absent; field semantics must be inferred from the review text after download.

Provenance

Source

figshare

Collection Method

Systematic literature review following PRISMA 2020 guidelines.

Freshness

Last updated 2026-05-25 06:03:28; freshness should be verified.