Cytokine Profiles and Immune Networks in 65 Chronic Spontaneous Urticaria Patients

65 antihistamine-refractory chronic spontaneous urticaria patients had serum levels of 15 cytokines measured at baseline and after 6 months of omalizumab treatment. The data, authored by Young-Min Ye and last updated in April 2026, was analyzed to identify cytokine imbalances and network architectures associated with heterogeneous treatment response categories.

Use Cases

• Identifying cytokine-based biomarkers for treatment response based on baseline IL-13 levels and compositional imbalance.
• Modeling immune network topology and connectivity based on cytokine interaction patterns described in the results.
• Predicting patient response categories (early/well-controlled, late/partly controlled, no-response) using multinomial regression on cytokine profiles.
• Analyzing longitudinal cytokine modulation based on paired measurements at baseline and month 6.

Strengths

• Includes longitudinal data with paired cytokine measurements from 65 patients at two time points.
• Analysis covers 15 specific cytokines, providing a multi-analyte profile.
• Patients were categorized into three distinct, clinically defined response groups (EW, LP, NR).
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is very small at 21.0 KB, indicating limited scope and sample size.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for some analyses.

Provenance

Source

figshare

Collection Method

Serum cytokine profiles were quantified using a multiplex bead-based assay from patients in a clinical study.

Freshness

Last updated 2026-04-20 04:13:27; freshness should be verified.