Cytokine Profiles in Maternal and Cord Blood from Term and Preterm Births

78 pregnancies contributed paired maternal peripheral and umbilical cord blood samples for profiling of 48 cytokines, chemokines, and growth factors. Tiantian Yu published this data on figshare in April 2026, investigating immune signatures associated with spontaneous preterm birth and preterm birth with premature rupture of membranes.

Use Cases

• Compare cytokine levels like M-CSF and SCF in cord blood between term and preterm deliveries.
• Identify distinct immune patterns, such as upregulation of IFN-γ and IL-2Rα, specific to spontaneous preterm birth (S-PTB).
• Analyze correlation networks among the 48 profiled immune mediators in fetal versus maternal compartments.
• Investigate broader reductions in eotaxin and HGF levels associated with PROM-PTB subtype in cord blood.
• Perform principal component analysis on global cytokine profiles to assess overlap across labor types.

Strengths

• Profiles 48 specific immune mediators including cytokines, chemokines, and growth factors.
• Includes paired samples from 78 pregnancies across three clinical groups.
• Data distinguishes between maternal peripheral blood and fetal umbilical cord blood compartments.

Limitations

• Small sample size of 78 pregnancies limits statistical power for subgroup analyses.
• Dataset scope is limited to 36.9 KB, indicating summary-level data rather than raw measurements.
• No column-level metadata or sample data is provided to verify individual cytokine values.

Provenance

Source

Tiantian Yu via figshare.

Collection Method

Multiplex profiling performed on collected blood samples.

Freshness

Last updated April 2026.