Cerebrospinal Fluid Cytokine Levels for Neurosyphilis Diagnosis and Progression Prediction

129 patients with syphilis were enrolled from April 2021 to April 2023 and categorized into common syphilis, asymptomatic neurosyphilis, and symptomatic neurosyphilis groups. The dataset likely contains measurements of 48 cytokines/chemokines in cerebrospinal fluid samples, combined with clinical indices, to identify biomarkers for disease progression. It was authored by Yu Zhao and shared under a CC-BY-4.0 license.

Use Cases

• Training machine learning models to distinguish neurosyphilis from common syphilis based on cytokine profiles.
• Identifying predictive biomarkers like IL-2Rα for forecasting progression from asymptomatic to symptomatic neurosyphilis.
• Developing age-stratified diagnostic models using cytokine combinations such as IL-2Rα and IP-10.
• Validating the diagnostic accuracy of a three-cytokine panel (RANTES, MIP-1β, IL-3) for syphilis detection.

Strengths

• Includes data from 129 patients across multiple clinical groups and a control group.
• Analyzes 48 cytokines/chemokines, providing a multi-feature view of cerebrospinal fluid.
• Reports specific performance metrics (AUC values) for identified biomarker panels.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 22.1 KB, indicating limited scope.
• Data may reflect temporal and population bias inherent to the single study from 2021-2023.

Provenance

Source

figshare, author Yu Zhao.

Collection Method

Cerebrospinal fluid samples were collected and analyzed from enrolled patients.

Time Range

April 2021 to April 2023.

Freshness

Last updated 2026-04-20 04:13:46; freshness should be verified.