CircRNA ceRNA Network in Tuberculosis-Infected Dendritic Cells

A 174.5 KB Excel dataset from a 2026 figshare upload by Xiaohong Sun. It contains a constructed competing endogenous RNA (ceRNA) regulatory network from dendritic cells infected with Mycobacterium tuberculosis strains H37Ra and BCG. The network includes 10 circRNAs, 41 miRNAs, and 145 mRNAs, with validation results for specific regulatory axes.

Use Cases

• Train models to predict circRNA-miRNA-mRNA interactions based on the described ceRNA network topology.
• Analyze gene enrichment in tuberculosis-related pathways like JAK-STAT and NF-κB based on the identified hub genes.
• Validate computational predictions of diagnostic biomarkers for tuberculosis using the provided ROC analysis results.

Strengths

• Includes a validated ceRNA network with 10 circRNAs, 41 miRNAs, and 145 mRNAs.
• Identifies four core genes (STAT1, BCL2, TRAF6, IL1A) enriched in tuberculosis pathways.
• Two regulatory axes were validated by qRT-PCR with diagnostic AUC >0.7.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The authors note findings are limited to experimental DC models and require further clinical validation.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare upload by author Xiaohong Sun.

Collection Method

Constructed from analysis of GEO datasets and predictions from circBank, CircInteractome, TargetScan, and miRanda databases.

Time Range

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Freshness

Last updated 2026-04 13 04:33:23; freshness should be verified.

Geography

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