Multi-Omics and In Vivo Data Linking Autonomic Dysfunction and Atrial Fibrillation

A research document from figshare, authored by Xiaohan Zhang and last updated on 2026-05-22, describes a study investigating the link between autonomic dysfunction and atrial fibrillation. The work integrates targeted plasma neurotransmitter profiling, atrial transcriptomes, and in vivo mouse model validation to identify CD47-mediated efferocytosis as a key mechanism. The dataset is a 20.6 KB DOCX file containing the study's methods and results.

Use Cases

• Identify potential drug targets for autonomic modulation in atrial fibrillation based on the described hub genes (CDKN2D, FYTTD1, LRR1, POPDC3).
• Validate bioinformatic findings on immune infiltration and efferocytosis using the described Ang II-infused mouse model data.
• Study the relationship between plasma neurotransmitter profiles and atrial fibrillation susceptibility based on the described autonomic-imbalance signature.
• Investigate the therapeutic potential of valsartan in reversing autonomic remodeling and inflammatory signaling as described in the in vivo validation.

Strengths

• Integrates multiple data types including clinical plasma profiling, transcriptomics, and in vivo validation as described in the methods.
• The underlying research employs machine-learning feature selection and in silico docking, suggesting a structured analytical approach.
• Released under a permissive CC-BY-4.0 license, allowing for broad reuse.

Limitations

• The dataset is a 20.6 KB DOCX document, which is a very small text summary rather than the underlying raw or processed numerical data.
• Column-level documentation and sample data are unavailable, making direct computational analysis impossible without the source data.
• The geographic and demographic scope of the clinical cohort is not specified.

Provenance

Source

figshare, author Xiaohan Zhang.

Collection Method

Describes a study using targeted LC-MS/MS profiling, transcriptome integration, bioinformatics, and an Ang II-infused mouse model.

Freshness

Last updated 2026-05-22 07:38:50; freshness should be verified.