iNTS-GMMA: Preclinical Vaccine Development Data Against Invasive Salmonella

Francesco Citiulo published a document on figshare in 2026 detailing the development of a bivalent GMMA-based vaccine candidate against invasive nontyphoidal Salmonella disease. The work describes genetic modifications to Salmonella strains, GMMA production under GMP conditions, and preclinical immunogenicity and safety results from mice and rabbits. The data supported the clinical evaluation of this vaccine candidate for use in sub-Saharan Africa.

Use Cases

• Reviewing preclinical development protocols for a novel GMMA-based vaccine based on the described methods.
• Analyzing immunogenicity results from animal models based on the described IgG and bactericidal activity data.
• Studying manufacturing and purification processes for outer membrane vesicle vaccines based on the described two-step filtration and formulation steps.

Strengths

• Document includes specific mortality statistics, citing a 14.7% case fatality ratio and 62,018 annual deaths worldwide.
• Describes a complete preclinical development pathway from genetic modification to toxicology studies.
• Data is licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• The primary data file is a 1.3 MB DOCX document; underlying raw experimental data is not provided in a structured, machine-readable format.
• Row count and column-level documentation are absent, limiting direct computational analysis.
• The dataset's scale is small (1.3 MB), which may indicate it is a summary document rather than a large primary data repository.

Provenance

Source

Francesco Citiulo via figshare.

Collection Method

Likely contains summarized results from laboratory experiments and animal studies conducted during vaccine development.

Freshness

Last updated 2026-06-02 08:48:51.

Geography

Research is focused on a disease primarily affecting sub-Saharan Africa.