Diagnostic Performance of Plasma p-Tau Biomarkers for Alzheimer's Disease: A Meta-Analysis

18 high-quality studies comprising 24 independent datasets and 4,736 participants were included in this network meta-analysis. The work compares the diagnostic accuracy of plasma phosphorylated tau isoforms (p-tau217, p-tau181, p-tau231) measured by mass spectrometry and immunoassays against cerebrospinal fluid or PET standards. The dataset, authored by Xiaofen Chen and last updated in June 2026, is shared under a CC-BY-4.0 license.

Use Cases

• Compare diagnostic accuracy of p-tau isoforms based on reported Area Under the Curve (AUC) values.
• Evaluate the performance of mass spectrometry versus immunoassay platforms for biomarker measurement.
• Assess the prognostic value of biomarkers for predicting cognitive decline from mild cognitive impairment to dementia.
• Analyze subgroup performance of biomarkers across different ethnic cohorts, such as Han Chinese and Western populations.

Strengths

• Analysis is based on 18 high-quality studies with 4,736 total participants, providing a substantial evidence base.
• Rigorous screening for statistical independence of cohorts, such as BioFINDER and ADNI, was performed.
• The dataset includes specific performance metrics like P-scores and incremental AUC gains with confidence intervals.

Limitations

• The dataset is a 14.3 KB DOCX file, suggesting it is a summary table or document rather than a raw data repository.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for direct computational analysis.

Provenance

Source

figshare, author Xiaofen Chen

Collection Method

Systematic review and network meta-analysis of published studies.

Freshness

Last updated 2026-06-03 06:45:15; freshness should be verified.

Geography

Includes data from Han Chinese and Western cohorts; specific geography is not detailed.