Rat Model Data on Diallyl Trisulfide Effects on Metabolic Syndrome Biomarkers

Diallyl trisulfide (DATS) downregulated PCSK-9 mRNA expression by 1.59-fold and increased LDL-R mRNA expression by 1.98-fold in a high-carbohydrate high-fat diet rat model. This dataset, uploaded by Parvej Ahmad to figshare, contains results from a study investigating the protective effects of a garlic-derived compound on metabolic syndrome parameters. The 672.0 KB file was last updated in May 2026 and is shared under a CC-BY-4.0 license.

Use Cases

• Analyzing correlations between PCSK-9/LDL-R axis modulation and plasma lipid levels based on described biochemical measurements.
• Modeling the effects of dietary interventions on inflammatory cytokine networks based on mRNA expression data for IL-1, IL-6, and TNF-α.
• Investigating the relationship between HMG-R expression/activity and cholesterol synthesis in a metabolic syndrome model.
• Studying the upregulation of PPAR-α, β, and γ receptors as a potential therapeutic mechanism for metabolic disorders.

Strengths

• Specific fold-change measurements are provided for key gene expressions, such as a 1.98-fold increase in LDL-R mRNA.
• The description details a multi-faceted analysis covering lipid profiles, inflammatory markers, and enzymatic activity.
• Data is associated with a clearly defined experimental model (HCHF diet-fed rats) and intervention (DATS).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 672.0 KB, indicating a limited scope of data.

Provenance

Source

figshare, author Parvej Ahmad.

Collection Method

Experimental data from a controlled rat model study with a high-carbohydrate high-fat diet and diallyl trisulfide intervention.

Freshness

Last updated 2026-05-29 04:48:26; freshness should be verified.