Antimicrobial Peptide Efficacy Against Periodontal Bacteria with Cigarette Smoke Exposure

Experimental results on the inhibitory activity of two synthetic LL37 derivatives against periodontal pathogens. The data includes measurements of bacterial growth inhibition for Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus oralis in the presence of cigarette smoke extract. The dataset was authored by Samaneh Keshavarz and last updated on 2026-04-28.

Use Cases

• Compare the efficacy of FK13a1-NH2 and KR12-NH2 peptides based on the described growth inhibition results.
• Analyze the interaction between antimicrobial peptides and cigarette smoke extract based on the described checkerboard and microdilution experiments.
• Model the impact of synthetic peptides on single-species versus multi-species biofilms based on the described confocal imaging results.

Strengths

• Includes specific quantitative results, such as 98% P. gingivalis growth inhibition with 500 μg/ml KR12-NH2 and 50% CSE.
• Covers three target periodontal bacteria (F. nucleatum, P. gingivalis, S. oralis) under controlled experimental conditions.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary data file is a DOCX document, which may require parsing to extract structured data.

Provenance

Source

figshare

Collection Method

Data was generated via laboratory techniques including microdilution testing, checkerboard experiments, and confocal imaging.

Freshness

Last updated 2026-04-28 05:27:50; freshness should be verified.