MPO-ANCA Vasculitis: B-Cell Receptor and Epitope Data from a Single-Center Study

A single-center study comparing naturally occurring and disease-associated autoantibodies in MPO-ANCA vasculitis. The dataset includes immunogenomic B-cell receptor sequencing data and serum IgG epitope mapping results from patients with active disease, patients in long-term remission, and healthy individuals. The work was authored by Dhruti P. Chen and last updated on 2026-06-02.

Use Cases

• Compare B-cell receptor clonotype diversity and dominance between patient and healthy cohorts based on bulk BCR sequencing.
• Identify shared or distinct MPO epitope signatures based on serum IgG mapping using a yeast surface display peptide library.
• Investigate the correlation between in vitro autoantibody production and BCR immunogenomic features described in the study.

Strengths

• Data is derived from a controlled, single-center cohort of patients and healthy individuals.
• Analysis includes paired BCR sequencing and epitope mapping, as described in the methods.
• Dataset is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is small at 141.7 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Peripheral blood mononuclear cells were screened to isolate MPO-specific B cells; BCR sequencing and epitope mapping were performed as described.

Freshness

Last updated 2026-06-02 08:12:24; freshness should be verified.

Geography

Data was collected from a single center; specific location is unknown.