Mouse Skeletal Muscle Fibroblast Gene Expression and Function Under Aldosterone Treatment

RNA sequencing data reveals 492 differentially expressed genes in neonatal mouse skeletal muscle fibroblasts after aldosterone treatment. The dataset, created by Chetan K. Gomatam and last updated in April 2026, includes results from in vitro proliferation and migration assays on fibroblasts from wild-type and dystrophic muscles. It provides insights into the direct effects of mineralocorticoid receptor signaling on fibroblast behavior in muscle health and disease.

Use Cases

• Identify gene expression changes in fibroblasts based on aldosterone treatment data.
• Compare fibroblast proliferation rates between neonatal and adult muscle sources.
• Analyze differences in scratch-wound closure kinetics between wild-type and dystrophic muscle fibroblasts.

Strengths

• Specific gene count (492) for differential expression is provided.
• Experimental conditions (aldosterone vs. vehicle, neonatal vs. adult, wild-type vs. dystrophic) are clearly described.
• Data is openly available under a CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown.
• The dataset is small (69.5 KB), indicating limited scope.

Provenance

Source

figshare, author Chetan K. Gomatam.

Collection Method

Data likely originates from RNA sequencing and in vitro assays on isolated mouse fibroblasts.

Freshness

Last updated 2026-04-20 04:13:35.